Pubblicazioni

Facoltà di Farmacia

Corso di Laurea Magistrale in Chimica e Tecnologia Farmaceutiche

Metodologie Speciali in Analisi Farmaceutica

AA 2011/2012

Docente: Prof. Antonino Lauria

Prof. Antonino Lauria

Curriculum Vitae - Pubblicazioni - Comunicazioni

ELENCO DELLE PUBBLICAZIONI

1. Passannanti, P. Diana, P. Barraja, F. Mingoia, A. Lauria, G. Cirrincione: “Pyrrolo[2,3-d][1,2,3]triazoles as Potential Antineoplastic Agents”. Heterocycles, 1998, 48, 1229-1235.

2. Passannanti, P. Diana, F. Mingoia, P. Barraja, A. Lauria, G. Cirrincione: “Pyrrolo[3,2-c][1,2,5]benzotriazocine: A New Ring System”. J. Heterocycl. Chem., 1998, 35, 1535-1537.

3. G. Cirrincione, A.M. Almerico, P. Barraja, P. Diana, A. Lauria, A. Passannanti, C. Musiu, A. Pani, P. Murtas, C. Minnei, M.E. Marongiu, P. La Colla: “Derivatives of the New Ring System Indolo[1,2-c]benzo[1,2,3]triazine with Potent Antitumor and Antimicrobal Activity”. J. Med. Chem., 1999, 42, 2561-2568.

4. P. Barraja, P. Diana, A. Lauria, A. Passannanti, A.M. Almerico, C. Minnei, S. Longu, D. Congiu, C. Musiu, P. La Colla: “Indolo[3,2-b]cinnolines with Antiproliferative, Antifungal and Antibacterial Activity”. Bioorg. Med. Chem., 1999, 7, 1591-1596.

5. P. Diana, P. Barraja, A. Lauria, A.M. Almerico, G. Cirrincione, A. G.Loi, E. Congeddu, C. Musiu, M. Putzolu, P. La Colla: “2-Triazenopyrroles: Synthesis and Biological Activity”. Eur. J. Med. Chem., 1999, 34, 353-360.

6. P. Diana, P. Barraja, A. Lauria, A.M. Almerico, G. Cirrincione, C. Minnei, S. Longu, D. Congiu, C. Musiu, P. La Colla: “Synthesis and Antiproliferative Activity of 2-Triazenothiophenes”. Anticancer Research, 1999, 19, 2127-2132.

7. P. Diana, A. Passannanti, P. Barraja, A. Lauria, G. Cirrincione: “Pyrrolo[2,3-b][1,4]benzo-thiazine. A New Ring System from Azidopyrroles”. Heterocylces, 1999, 51, 2103-2109.

8. P. Diana, P. Barraja, A. Lauria, A.M. Almerico, G. Dattolo, G. Cirrincione: “Pyrrolo[2,1-d][1,2,3,5]tetrazines, a New Class of Azolotetrazines Related to the Antitumor Drug Temozolomide”. Synthesis. 1999, 12, 2082-2086.

9. P.Diana, P.Barraja, A.Lauria, A.M.Almerico, G.Dattolo, G.Cirrincione: “Protonation of Aminoindoles” Tetrahedron, 2000, 56, 5177-5183.

10. A.Lauria, P.Diana, P.Barraja, A.M.Almerico, G.Cirrincione, and G.Dattolo: “Pyrrolo[3,4-e][1,2,3]triazolo[1,5-a]pyrimidine and Pyrrolo[3,4-d][1,2,3]-triazolo[1,5-a]pyrimidine. New Tricyclic Ring Systems of Biological Interest.” J. Heterocycl. Chem., 2000, 37, 747-750.

11. A.M.Almerico, A.Lauria, P.Diana, P.Barraja, G.Cirrincione, and G.Dattolo: “1-b-D-Ribofuranosyl-pyrroles and Indoles as Potential Antiviral Agents.” Arkivoc, 2000, 1, 486-496.

12. P.Diana, P.Barraja, A.Lauria, A.M.Almerico, G.Dattolo, and G.Cirrincione: “Pyrrolo[2,1-d][1,2,3,5]tetrazinones Deaza Analogues of Temozolomide with Potent Antitumor Activity.” Il Farmaco, 2000, 55, 200-201.

13. F.Mingoia, P.Diana, P.Barraja, A.Lauria, and A.M.Almerico: “Dipyrrolo-[1,2-a:1',2'-c]quinazoline, a New Ring System of Biological Interest.” Heterocycles, 2000, 53, 1975-1985.

14. P.Barraja, P.Diana, A.Lauria, A.M.Almerico, G.Dattolo and G.Cirrincione: “2-Diazo-2-H-indoles.” Helvetica Chimica Acta, 2001, 84, 2212-2219.

15. A.M.Almerico, A.Montalbano, P.Diana, P.Barraja, A.Lauria, G.Cirrincione, G.Dattolo, “On the preparation of 1-aryl-2-heteroaryl- and 2-aryl-1-heteroaryl-pyrroles as useful building blocks for biologically interesting heterocycles”, Arkivoc, 2001, 129-142.

16. A.M. Almerico, F.Mingoia, P.Diana, P. Barraja, A.Montalbano, A.Lauria, R.Loddo, L.Sanna, D.Delpiano, M.G.Setzu, C.Musiu: “Pyrrolo[1,2-f]phenanthridines and Related Non-rigid Analogues as Antiviral Agents.” Eur. J. Med. Chem., 2002, 37, 3-10.

17. P. Diana, P.Barraja, A.Lauria, A.Montalbano, A.M.Almerico, G.Dattolo, and G.Cirrincione: “Pyrrolo[2,1-c][1,2,4,]triazines from 2-Diazopyrroles: Synthesis and Antiproliferative Activity.”, Eur. J. Med. Chem., 2002, 37, 267-272.

18. P. Barraja, P. Diana, A.Lauria, A. M. Almerico, G. Dattolo, G. Cirrincione “2-Diazoindoles: Building Blocks for the Synthesis of Antineoplastic Agents” Il Farmaco, 2002, 57, 97-100.

19. P.Barraja, P.Diana, A.Lauria, A.Montalbano, A.M.Almerico, G.Dattolo, G.Cirrincione “2-Triazenoindoles: Synthesis and Biological Activity”, Anticancer Res., 2002, 22, 837-840.

20. A.Lauria, P. Diana, P. Barraja, A. Montalbano, G. Cirrincione, G. Dattolo, A.M. Almerico: “New Tricyclic Systems of Biological Interest. Annelated 1,2,3-Triazolo[1,5-a]pyrimidines Through Domino Reaction of 3-Azidopyrroles and Methylene Active Nitriles” Tetrahedron, 2002, 58, 9723-9727.

21. A. Montalbano, P. Diana, P. Barraja, A.Lauria, G. Cirrincione, G. Dattolo, A.M. Almerico: “Pyrimido[5,4-c]pyrrolo[2,1-a]isoquinoline as Potential DNA-Interactive Ring System” Arkivoc, 2002, 264-273.

22. P. Diana, P. Barraja, A.Lauria, A. Montalbano, A.M. Almerico, G. Dattolo, G. Cirrincione, G. Viola, F. Dall’Acqua: “Pyrrolo[2,1-d][1,2,3,5]tetrazine-4(3H)-ones, a New Class of Azolotetrazines with Potent Antitumor Activity.” Bioorg. Med. Chem., 2003, 11, 2371-2380.

23. P. Barraja, P. Diana , A.Lauria, A. Montalbano, A.M. Almerico, G. Dattolo, G. Cirrincione, G. Viola, F. Dall'Acqua, “Pyrrolo[2,3-h]quinolinones: Synthesis and Photochemotherapic Activity” Bioorg. Med. Chem. Lett., 2003, 13, 2809-2811.

24. P. Barraja, P. Diana, A.Lauria, A. Montalbano, A.M. Almerico, G. Dattolo, G. Cirrincione: “Synthesis of 8,9,10,11-Tetrahydroindolo[2,1-c]benzo[1,2,4]triazine. A new Ring System”. Heterocycles, 2003, 60, 2519-2525.

25. A.Lauria, C. Patella, P. Diana, P. Barraja, A. Montalbano, G. Cirrincione, G. Dattolo, A.M. Almerico: “ New tetracyclic ring System of Biological Interest. Indolo[3,2e][1,2,3]triazolo [1,5-a]pyrimidines through domino reaction of 2-azidoindole”. Heterocycles, 2003, 60, 2669-2675.

26. A.M. Almerico, A.Lauria, M. Tutone, P. Diana , P. Barraja, A. Montalbano, , G. Cirrincione, G. Dattolo: “A multivariate analysis on non-nucleoside HIV-1 reverse transcriptase inhibitors and resistance induced by mutation”. QSAR & Comb. Sci., 2003, 22, 984-996.

27. A.Lauria, P. Diana , P. Barraja, A. Montalbano, G. Dattolo , G. Cirrincione, A.M. Almerico: “Docking of indolo- and pyrrolo-pyrimidines to DNA. New DNA-interactive polycycles from amino-indoles/pyrroles and BMMA”. Arkivoc, 2004, 5, 263-271.

28. P. Barraja, P. Diana, A.Lauria, A. Montalbano, A.M. Almerico, G. Dattolo, G. Cirrincione: “Synthesis and Antiproliferative Activity of [1,2,4]triazino[4,3-a]indoles”. Anticancer Research, 2004, 24, 3775-3780.

29. P. Barraja, P. Diana, A.Lauria, A. Montalbano, A.M. Almerico, G. Dattolo, G. Cirrincione: “Synthesis and Antiproliferative Activity of [1,2,3,5]tetrazino[5,4-a]indoles, a New Class of Azolo-tetrazinones”. Bioorganic Med. Chem., 2005, 13, 295-300.

30. A.Lauria, M. Bruno, P. Diana , P. Barraja, A. Montalbano, G. Cirrincione, G. Dattolo, A.M. Almerico: “Annelated Pyrrolo-pyrimidines from Amino-cyano-pyrroles and BMMAs as Leads for New DNA-interactive Ring Systems”. Bioorganic Med. Chem., 2005, 13, 1545-1553.

31. P. Barraja, L. Sciabica, P. Diana, A.Lauria, A. Montalbano, A.M. Almerico, G. Dattolo, G. Cirrincione, S. Disarò, G. Basso, G. Viola, F. Dall’Acqua: “Synthesis and Photochemoterapic Activity of Thiopyrano[2,3-e]indol-2-ones”. Bioorganic Med. Chem. Lett., 2005, 15, 2291-2294.

32. A.M. Almerico, F. Mingoia, P. Diana, P. Barraja, A.Lauria, A. Montalbano, G. Cirrincione, G. Dattolo: “1-Methyl-3H-pyrazolo[1,2-α]benzo[1,2,3,4]tetrazin-3-ones. Design, Synthesis and Biological Activity of New Antitumor Agents”, J. Med. Chem., 2005, 48, 2859-2866.

33. A.R. Katritzky, I. Tulp, D.C. Fara, A. Lauria, U. Maran, W.E. Acree: “A General Treatment of Solubility. 3. Principal Component Analysis (PCA) of the Solubilities of Diverse Solutes in Diverse Solvents”, J. Chem. Inf. Model., 2005, 45, 913-923.

34. A.M. Almerico, M. Tutone, A. Lauria, P. Diana, P. Barraja, A. Montalbano, G. Cirrincione, G. Dattolo: “A multivariate analysis on HIV-1 protease inhibitors and resistance induced by mutation”, J. Chem. Inf. Model., 2006, 46, 168-179.

35. A. Lauria, P. Diana, P. Barraja, A. Montalbano, G. Cirrincione, G. Dattolo, A.M.Almerico: “MADoSPRO: a new Approach to molecular modelling studies on a series of DNA minor groove binders”, QSAR & Comb. Sci., 2006, 25, 252-262.

36. A. Lauria, C. Patella, P. Diana, P. Barraja, A. Montalbano, G. Cirrincione, G. Dattolo, A.M. Almerico: “A synthetic approach to new polycyclic ring system of biological interest through domino reaction: indolo[2,3-e][1,2,3]triazolo[1,5-a]pyrimidine”, Tetrahedron Lett., 2006, 47, 2187–2190.

37. A. Lauria, M. Ippolito, A.M. Almerico: “Molecular docking approach on the topoisomerase I inhibitors series included in the NCI anti-cancer agents mechanism database” J. Mol. Mod., 2007, 13, 393-400.

38. P. Diana, A. Martorana, P. Barraja, A. Lauria, A. Montalbano, A.M. Almerico, G. Dattolo, G. Cirrincione: “Isoindolo[2,1-c]benzo[1,2,4]triazines: a new ring system with antiproliferative activity”, Bioorg. Med. Chem., 2007, 15, 343-349.

39. A.M. Almerico, M. Tutone, M. Ippolito, A. Lauria, “Molecular modelling and QSAR in the discovery of HIV-1 integrase inhibitors”, Curr. Computer-Aided Drug Des., 2007, 3, 214-233.

40. A. Lauria, C. Patella, M. Ippolito, A.M. Almerico, “Docking and synthesis of pyrrolopyrimidodiazepinone derivatives (PPDs) and their precursors: New scaffolds for DNA-interacting agents”, Theochem. J. Mol. Struct., 2007, 819; 26-31.

41. A. Lauria, A. Montalbano, P. Barraja, G. Dattolo, A.M. Almerico, “DNA minor groove binders: an overview on molecular modeling and QSAR approaches”, Curr. Med. Chem., 2007, 14, 2136-2160.

42. A. Lauria, M. Ippolito, A.M. Almerico, “Molecular dynamics studies on HIV-1 protease: a comparison of the flap motions between wild type protease and the M46I/G51D double mutant”, J. Mol. Mod., 2007, 13, 1151-1156.

43. A. Lauria, C. Patella, G. Dattolo, A.M. Almerico, “Design and Synthesis of 4-Substituted Indolo[3,2-e][1,2,3]triazolo[1,5-a]pyrimidine Derivatives with Antitumor Activity”, J. Med. Chem., 2008, 51(7), 2037-2046.

44. A. Lauria, A. Guarcello, G. Dattolo, A.M. Almerico, “Bis-1,2,4-triazolo[4,3-a:3',4'-c]quinoxalines of pharmaceutical interest from 1,3-dipolar cycloaddition”, Tetrahedron Lett., 2008, 49(11), 1847-1850.

45. A. Lauria, I. Abbate, C. Patella, N. Gambino, A. Silvestri, G. Barone, A.M. Almerico, “Pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine: a new ring system through Dimroth rearrangement”, Tetrahedron Lett., 2008, 49(35), 5125-5128.

46. G. Barone, C.F. Guerra, N. Gambino, A. Silvestri, A. Lauria, A.M. Almerico, F.M. Bickelhaupt, “Intercalation of daunomycin into stacked DNA base pairs. DFT study of an anticancer drug”, J. Biomol. Struct. Dyn., 2008, 26(1), 115-129.

47. A.M. Almerico, M. Tutone, A. Lauria, “Docking and multivariate methods to explore HIV-1 drug-resistance: a comparative analysis”, J. Comput. Aided Mol. Des., 2008, 22(5), 287-297.

48. A.M. Almerico, M. Tutone, A. Lauria, “In-silico screening of new potential Bcl-2/Bcl-xl inhibitors as apoptosis modulators”, 2009, J. Mol. Mod., 2009, 15(4),349-55.

49. A. Lauria, M. Ippolito, A.M. Almerico, “Inside the Hsp90 inhibitors binding mode through induced fit docking”, J. Mol. Graphics Modell., 2009, 27(6), 712-722.

50. A. Lauria, M. Ippolito, A.M. Almerico, “Combined use of PCA and QSAR/QSPR to predict the drugs mechanism of action. An application to the NCI ACAM Database”, QSAR & Comb. Sci., 2009, 28, 387-395.

51. A.M. Almerico, M. Tutone, A. Lauria, “A QSAR study investigating the potential anti-HIV-1 effect of some Acyclovir and Ganciclovir analogs”, ARKIVOC, 2009, viii, 85-94.

52. A. Lauria, M. Ippolito, A.M. Almerico, “Principal component analysis on molecular descriptors as an alternative point of view in the search of new Hsp90 inhibitors”, J. Comp. Biol. Chem., 2009, doi:10.1016/j.compbiolchem.2009.07.010.